Expression of monolysocardiolipin acyltransferase activity is regulated in concert with the level of cardiolipin and cardiolipin biosynthesis in the mammalian heart |
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| Authors: | William A Taylor Fred Y Xu Brian J Ma Thomas C Mutter Vernon W Dolinsky Grant M Hatch |
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| Institution: | (1) Departments of Pharmacology and Therapeutics, Centre on Aging, Center for Research and Treatment of Atherosclerosis, University of Manitoba, Winnipeg, Canada;(2) Internal Medicine and Biochemistry and Medical Genetics, Centre on Aging, Center for Research and Treatment of Atherosclerosis, University of Manitoba, Winnipeg, Canada;(3) Department of Immunology, University of Alberta, Edmonton, Canada;(4) Department of Biochemistry, University of Alberta, Edmonton, Canada |
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| Abstract: | Background Monolysocardiolipin acyltransferase (MLCL AT) catalyzes the acylation of monolysocardiolipin to cardiolipin in mammalian tissues. We previously reported that cardiac cardiolipin levels, MLCL AT and cardiolipin synthase activities were all elevated in rats made hyperthyroid by thyroxine treatment. In this study, we examined if cardiac mitochondrial MLCL AT activity was dependent upon the biosynthesis and level of cardiolipin in the heart. Rat heart mitochondrial MLCL AT activity was determined under conditions in which the levels of cardiac cardiolipin and cardiolipin synthase activity were either reduced or unaltered using four different disease models in the rat. In addition, these parameters were examined in a murine model of cardiac cell differentiation. |
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