MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function |
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| Authors: | Vered Maytal-Kivity Noa Reis Kay Hofmann Michael H Glickman |
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| Institution: | 1. Dept. of Biology and Institute for Catalysis Science and Technology (ICST) Technion, Israel Institute of Technology, Haifa, Israel
2. Bioinformatics Group, MEMOREC Stoffel GmbH, K?ln, Germany
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| Abstract: | Background Three macromolecular assemblages, the lid complex of the proteasome, the COP9-Signalosome (CSN) and the eIF3 complex, all consist of multiple proteins harboring MPN and PCI domains. Up to now, no specific function for any of these proteins has been defined, nor has the importance of these motifs been elucidated. In particular Rpn11, a lid subunit, serves as the paradigm for MPN-containing proteins as it is highly conserved and important for proteasome function. |
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