The platelet as a model for chemical genetics |
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| Authors: | Flaumenhaft Robert Sim Derek S |
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| Affiliation: | Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. rflaumen@bidmc.harvard.edu |
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| Abstract: | Chemical genetics is an emerging strategy in chemical biology that promises to bring the power of true genetics to mammalian systems and facilitate the transfer of biological discoveries to therapeutics. The platelet is an anucleate cell with several features that render it suitable for chemical genetic analysis. This review addresses the benefits and challenges of chemical genetics using platelets as a model system. |
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