| 甲磺酸多沙唑嗪的合成 |
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| 引用本文： | 崔运启,徐成. 甲磺酸多沙唑嗪的合成[J]. 化学研究与应用, 2011, 23(1): 122-124 |
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| 作者姓名： | 崔运启 徐成 |
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| 作者单位： | 黄淮学院化学化工系,河南,驻马店,463000 |
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| 基金项目： | 河南省科技发展计划资助项目 |
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| 摘 要： | 甲磺酸多沙唑嗪(doxazosin mesylate,Ⅰ)的化学名为1-(4-氨基-6,7-二甲氧基-2-喹唑啉基)-4-(1,4-苯骈二恶烷-2-甲酰基)哌嗪甲磺酸盐,是一种新型的高选择性α1受体阻滞剂[1],半衰期长,且有明显的降压和降脂作用,同时对单纯性前列腺增生引起的排尿困难具有良好的作用.目前已成为国内外治疗轻中度高血压的一线药物[2,3,4].
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| 关 键 词： | 甲磺酸多沙唑嗪 邻苯二酚 2.3-二溴丙酸乙酯 合成 |
Synthesis of doxazosin mesylate |
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| CUI Yun-qi,XU Cheng. Synthesis of doxazosin mesylate[J]. Chemical Research and Application, 2011, 23(1): 122-124 |
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| Authors: | CUI Yun-qi XU Cheng |
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| Affiliation: | CUI Yun-qi,XU Cheng(Department of Chemistry Engineering,Huanghuai University,ZhuMaDian 463000,China) |
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| Abstract: | Doxazosin Mesylate was synthesized from catechol and 2,3-dibromo-propanoic acid ethyl ester by cyclization,piperazidintion,condensation,and salification with the yield of 80.2%.The reaction conditions was mild and suitable for industrialization. |
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| Keywords: | doxazosin mesylate catechol 2 3-dibromo-propanoic acid ethyl ester synthesis |
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