Synthesis of analogs of pyridoxal 5′-phosphate and pyridoxamine 5′-phosphate |
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Authors: | N. A. Drobinskaya L. V. Ionova M. Ya. Karpeiskii V. L. Florent'ev |
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Affiliation: | (1) Institute of Molecular Biology AS USSR, USSR;(2) Second Moscow Medical Institute, USSR |
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Abstract: | The following analogs of pyridoxamine 5-phosphate (PAMP) have been synthesized by the direct phosphorylation of the corresponding amines: 2-nor-PAMP, 6-methyl-2-nor-PAMP, and 6-methyl-PAMP. A method for the synthesis of analogs of pyridoxal 5-phosphate (PLP) by the phosphorylation of the Schiff's bases of the corresponding aldehydes with p-phenetidine and subsequent hydrolysis on a sulfonated resin has been worked out. 2-Nor-PLP, 6-methyl-2-nor-PLP, and 6-methyl-PLP have been obtained with yields of 53–73%. The spectral properties of the compounds obtained have been investigated.The authors heartily thank Academician A. E. Braunshtein for his constant interest in this work and for valuable advice. |
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