Recyclable heterogeneous copper oxide on alumina catalyzed coupling of phenols and alcohols with aryl halides under ligand-free conditions |
| |
Authors: | Swapna Kokkirala Murthy Sabbavarapu Narayana Jyothi Mocharla Tarani Nageswar Yadavalli Venkata Durga |
| |
Institution: | Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500607, India. |
| |
Abstract: | An efficient alumina-supported CuO-catalyzed O-arylation of phenols and aliphatic alcohols with various aryl as well as heteroaryl halides under ligand-free conditions are reported. This protocol provides a variety of diaryl ether and bis-diaryl ether motifs by reacting different aryl/aliphatic halides with differently substituted phenols and saturated alcohols in the presence of a catalytic amount of CuO on alumina and KOH as a base at moderate temperature under nitrogen atmosphere. The described methodology is simple, straightforward and efficient to afford the cross-coupled products in high yields under ligand-free conditions. The explored catalyst is inexpensive, air-stable and recyclable up to three cycles. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|