Conjugated polymer nanoparticles for small interfering RNA delivery |
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| Authors: | Moon Joong Ho Mendez Eladio Kim Yong Kaur Aman |
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| Affiliation: | Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th St., Miami, FL 33199, USA. jmoon@fiu.edu |
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| Abstract: | Loosely aggregated conjugated polymer nanoparticles (CPNs) were used as nontoxic and efficient small interfering RNA (siRNA) delivery vehicles with delivery visualization. A significant down regulation (94%) of a target gene was achieved by transfection of HeLa cells with the CPNs/siRNA complexes, supporting CPN as a promising siRNA delivery carrier. |
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