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Study of open-tubular micro-capillary liquid chromatography
Authors:D. Ishii  T. Tsuda  K. Hibi  T. Takeuchi  T. Nakanishi
Abstract:Capillary columns in gas chromatography, first proposed by Golay [1,2], have become well established [3] which have extremely high column efficiencies and separabilities. Everyone could imagine it to be a great tool if such a kind of high efficiency column could be established in liquid chromatography (LC). Microcapillary liquid chromatography (MCLC) may be one way of achieving high-efficiency in terms of theoretical plates. Few papers were published in this field before 1976 [4–6], but more recently, after 1977 [7–15], this field has become one of topical interest in liquid chromatography. Temporarily there are two microcapillary liquid chromatography, that is: ?open-tubular”? [7,8,10–15] and ?packed”? [9] MCLC. In this presentation we focus on open-tubular microcapillary liquid chromatography and a review contemporary developments of ours and others.
Keywords:Liquid chromatography, HPLC  Capillary, glass  Review on open tubular micro capillary LC  Technical solutions of the problems in zero dead volume connections  Capillary LC/MS combination
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