Total synthesis of (+)-pinnatoxin A |
| |
Authors: | Stivala Craig E Zakarian Armen |
| |
Affiliation: | Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306-4390, USA. |
| |
Abstract: | A convergent enantioselective total synthesis of (+)-pinnatoxin A is described. The synthesis capitalizes on the highly diastereoselective Ireland-Claisen rearrangement of an acyclic alpha-branched allylic ester to set the quaternary stereogenic center at the core of the spiroimine ring system along with the adjacent tertiary stereocenter. The all-carbon macrocyclic ring system was formed by ring-closing metathesis. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|