A catalytic route to ampakines and their derivatives |
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| Authors: | Mulzer Michael Coates Geoffrey W |
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| Affiliation: | Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853-1301, United States. |
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| Abstract: | A catalytic domino reaction that efficiently provides access to an important class of heterocycles, the ampakines, is reported. Our approach is based on the cobalt-catalyzed hydroformylation of dihydrooxazines and allows for the facile synthesis of the pharmaceutically interesting compound CX-614 and related substances. |
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