Enantioselective synthesis of axially chiral hydroxy carboxylic acid derivatives by rhodium-catalyzed [2 + 2 + 2] cycloaddition |
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Authors: | Ogaki Shuichiro Shibata Yu Noguchi Keiichi Tanaka Ken |
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Affiliation: | Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan. |
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Abstract: | Axially chiral hydroxy carboxylic acid derivatives were successfully synthesized with high yields and ee values by the cationic rhodium(I)/axially chiral biaryl bisphosphine complex-catalyzed enantioselective [2 + 2 + 2] cycloaddition. Axially chiral hydroxy and dihydroxy carboxylic acid derivatives, bearing the aryl group at the ortho-position of the alkoxycarbonyl group, were also synthesized with high regio- and enantioselectivity. |
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