A convenient one-pot preparation of 2-methyl-3-(phenylthio- methyl)quinolines from Morita-Baylis-Hillman adducts and their oxidation to the corresponding sulfones |
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| Authors: | Ramesh Chintakunta Lei Po-Min Kavala Veerababurao Kuo Chun-Wei Yao Ching-Fa |
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| Affiliation: | Department of Chemistry, National Taiwan Normal University, 88 Sec. 4 Tingchow Road, Taipei 116, Taiwan. |
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| Abstract: | A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl)quinolines from Morita-Baylis-Hillman adducts via conjugate addition of thiols followed by reductive cyclization with Fe/AcOH was developed. The 2-methyl-3-(phenylthiomethyl)quinolines were transformed into 2-methyl-3-(phenylsulfonylmethyl)quinolines via m-CPBA-mediated oxidation. |
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