| First Magnesium-mediated Carbonyl Benzylation in Water |
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| 引用本文： | 邓维 谭翔辉 刘磊 郭庆祥. First Magnesium-mediated Carbonyl Benzylation in Water[J]. 中国化学, 2004, 22(7): 747-750. DOI: 10.1002/cjoc.20040220726 |
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| 作者姓名： | 邓维 谭翔辉 刘磊 郭庆祥 |
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| 作者单位： | DepartmentofChemistry,UniversityofScienceandTechnologyofChina,Hefei230026,China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China (No. 20332020). |
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| 摘 要： | Catalyzed by AgNO3, Mg was found for the first time to be able to mediate the coupling reaction between aromatic aldehydes and benzyl bromide or chloride in water. The yields were slightly higher than the recent results for Mg-mediated allylation despite the fact that aqueous benzylation is intrinsically much harder than allylation. It was also found that the coupling reaction was chemoselective for aromatic aldehydes over aliphatic aldehydes, and chemoselective for aromatic aldehydes over aromatic ketones.
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| 关 键 词： | 羰基 苄基化作用 水溶液 绿色化学 镁 化学敏感性 巴比反应 |
First Magnesium-mediated Carbonyl Benzylation in Water |
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| DENG,Wei TAN,Xiang-Hui LIU,Lei GUO,Qing-Xiang. First Magnesium-mediated Carbonyl Benzylation in Water[J]. Chinese Journal of Chemistry, 2004, 22(7): 747-750. DOI: 10.1002/cjoc.20040220726 |
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| Authors: | DENG Wei TAN Xiang-Hui LIU Lei GUO Qing-Xiang |
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| Affiliation: | DENG,Wei TAN,Xiang-Hui LIU,Lei GUO,Qing-Xiang*Department of Chemistry,University of Science and Technology of China,Hefei 230026,China |
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| Abstract: | Catalyzed by AgNO3, Mg was found for the first time to be able to mediate the coupling reaction between aromatic aldehydes and benzyl bromide or chloride in water. The yields were slightly higher than the recent results for Mg-mediated allylation despite the fact that aqueous benzylation is intrinsically much harder than allylation. It was also found that the coupling reaction was chemoselective for aromatic aldehydes over aliphatic aldehydes, and chemoselective for aromatic aldehydes over aromatic ketones. |
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| Keywords: | green chemistry aqueous medium Barbier reaction Mg chemoselectivity |
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