Synthesizing the tetracyclic core of nanolobatolide |
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| Authors: | Chang Le Jiang Hao Fu Junkai Liu Bin Li Chuang-chuang Yang Zhen |
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| Affiliation: | Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China. |
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| Abstract: | A concise synthetic pathway that enables the stereoselective construction of the tetracyclic core of nanolobatolide has been developed by applying a tandem ring-closing metathesis (RCM) reaction of dienynes, a Eu(fod)(3)-catalyzed intermolecular Diels-Alder reaction, and a biomimetic epoxide opening reaction as key steps. |
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