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Surface-engineered polyelectrolyte multilayer capsules: synthetic vaccines mimicking microbial structure and function
Authors:De Geest Bruno G  Willart Monique A  Lambrecht Bart N  Pollard Charlotte  Vervaet Chris  Remon Jean Paul  Grooten Johan  De Koker Stefaan
Institution:Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Belgium. br.degeest@ugent.be
Abstract:Immunizing: to evoke highly potent immune responses against recombinant antigens, hollow capsules consisting of layers of dextran sulphate and poly-L-arginine that encapsulate the antigen ovalbumin (orange circles) were coated with immune-activating CpG-containing oligonucleotides (green). These capsules were readily internalized by dendritic cells and showed activity in further immunization experiments.
Keywords:antigens  drug delivery  immunology  polycations  self‐assembly
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