Hexafluoroacetone as a Protecting and Activating Reagent. Regioselective Esterification of Aspartic, Malic, and Thiomalic Acid |
| |
Authors: | Ksenia Pumpor Elisabeth Windeisen Jan Spengler Fernando Albericio Klaus Burger |
| |
Affiliation: | (1) Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028 Barcelona, Spain;(2) CIBER-BBN, Networking Centre on Bioengineering Biomaterials and Nanomedicine, Barcelona Science Park, University of Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain;(3) Department of Organic Chemistry, University of Barcelona, Mart? i Franqu?s 1-11, 08028 Barcelona, Spain |
| |
Abstract: | Hexafluoroacetone reacts with -functionalized ,-dicarboxy acids like aspartic, malic, and thiomalic acid to give exclusively five-membered lactones. The -carboxylic groups remain unaffected and can be derivatized separately. They can be linked i.a. to orthogonal protecting groups or multivalent alcohols like pentaerythritol to give synthetically valuable building blocks. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|