Syntheses and insecticidal activities of novel 2,5-disubstituted 1,3,4-oxadiazoles |
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| Authors: | Xiumian Zheng Yanli Wang Qingchun Huang Gonghua Song |
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| Affiliation: | a Shanghai Key Lab of Chemistry Biology, Institute of Pesticides and Pharmaceuticals, East China University of Science and Technology, P.O. Box 544, Shanghai 200237, PR China
b State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, PR China |
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| Abstract: | Nine novel symmetrical and asymmetrical 2,5-disubstituted 1,3,4-oxadiazoles have been synthesized by a facile and mild method with high yield. Meantime, it was found that the fluorine was easy substituted by hydrazine in polyhalogen-substituted aroyl hydrazine. The preliminary bioassay tests show that two of the compounds (D5 and D6) exhibited a significant insecticidal activity (LC50=116.02 and 70.93 mg l−1) on armyworm, Leucania separata Walker. Using the Drug Discovery Workbench (DDW) (Cerius2), structure-activities relationship was studied. |
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| Keywords: | Fluoroaryl 1,3,4-Oxadiazoles Insecticidal activity Armyworm |
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