Reconstruction of Optical Energy Deposition for Backward Optoacoustic Imaging

Visualizing optical properties, such as the optical absorption coefficient, helps us to obtain structural information of biological tissues. In this paper, we present an efficient reconstruction algorithm for optical energy deposition in backward optoacoustic imaging. Note that econstruction of optical energy deposition is the first step to imaging the optical absorption coefficient distribution. This algorithm is derived from the optoacoustic wave equations with line focusing, in which the focusing techniques were utilized to reduce the reconstruction problem from three dimensions (3-D) to one dimension (1-D). Simulations and experiments were conducted to verify efficacy of this algorithm. In the simulations, optoacoustic signals were generated based on the solution of the optoacoustic wave equations. In the experiments, a 3-D backward mode optoacoustic imaging system was built. The system consisted of a Nd YAG laser for optical irradiation and an acoustic detection system with a broadband hydrophone. A phantom was used to illustrate validity of the proposed algorithm. The results show that optical energy deposition can be efficiently reconstructed in both simulations and experiments.