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Preparation,X-ray structure and reactivity of a stable glycosyl iodide |
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| Authors: | Bickley Jamie Cottrell Jennifer A Ferguson John R Field Robert A Harding John R Hughes David L Kartha K P Ravindanathan Law Jayne L Scheinmann Feodor Stachulski Andrew V |
| Affiliation: | The Robert Robinson Laboratories, Department of Chemistry, University of Liverpool, Liverpool, UK L69 7ZD. |
| Abstract: | Highly selective reaction of methyl tetra-O-pivaloyl-beta-D-glucopyranuronate 2 with iodotrimethylsilane or (Me3Si)2 and I2 affords, in excellent yield, the 'disarmed' glycosyl iodide 1 which has good stability at 20 degrees C and excellent stability at 0 degrees C; the X-ray crystal structure of 1 is described, along with a comparison of its utility as a glycosyl donor to that of the corresponding bromide. |
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