Determination of nicotinamide (NA) using its polarographic catalytic wave in the presence of KIO3 |
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| Authors: | J F Song Y J Su W Guo |
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| Institution: | (1) Institute of Electroanalytical Chemistry, Northwest University, Xi’an, 710069, People’s Republic of China e-mail: eact@nwu.ed.cn, CN;(2) Agriculture College in South China University of Tropical Agriculture, Hainan 571737, People’s Republic of China, CN |
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| Abstract: | Nicotinamide (NA) yields a polarographic catalytic wave with a peak potential –1.38 V (vs. SCE) in 0.1 mol/L HAc-NaAc (pH
4.7)/4 × 10–3 mol/L KIO3 buffer solution. The sensitivity of the catalytic wave increased in one order of magnitude as compared to that of the responding
reduction wave without KIO3. Based on this observation, a new method for the determination of NA was recommended. The second order derivative peak current
was proportional to the NA concentration in the range of 5 × 10–8 – 6 × 10–7 mol/L. 0.11-fold vitamin B1, 0.13-fold B2, 0.14-fold B6 and 8-fold nicotinic acid amounts do not interfere the determination of 1 × 10–6 mol/L NA. The proposed method was used to determine the NA content in multivitamin tablets, with good agreement to the declared
amount.
Received: 25 October 1999 / Revised: 28 March 2000 / /Accepted: 31 March 2000 |
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