2-Alkylindoles via palladium-catalyzed reductive cyclization of ethyl 3-(o-trifluoroacetamidophenyl)-1-propargyl carbonates |
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| Authors: | Ilaria Ambrogio Giancarlo Fabrizi |
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| Institution: | Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università degli Studi ‘La Sapienza’, P.le A. Moro5, 00185 Roma, Italy |
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| Abstract: | The reaction of ethyl 3-(o-trifluoroacetamidophenyl)-1-propargyl carbonates with formate anions in the presence of Pd(PPh3)4 affords 2-alkylindoles in good to excellent yields. |
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| Keywords: | Alkylindoles Cyclization Palladium Alkynes Propargyl esters |
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