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Facile synthesis of 9-(arenethenyl)purines via Heck reaction of 9-vinylpurines and aryl halides |
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| Authors: | Wei-Sheng Huang Yihan Wang Raji Sundaramoorthi R Mathew Thomas David Wen Shuangying Liu Scott P Lentini Sasmita Das Geetha Banda Tomi K Sawyer William C Shakespeare |
| Institution: | ARIAD Pharmaceuticals, Inc., 26 Landsdowne Street, Cambridge, MA 02139, United States |
| Abstract: | The first example of a Heck reaction with 9-vinylpurines and aryl halides is described. It gives exclusively E-9-(arenethenyl)purines in high yields. Subsequent hydrogenation furnishes 9-(arenethyl)purines quantitatively. |
| Keywords: | 9-Vinylpurine Heck reaction 9-(Arenethenyl)purine 9-(Arenethyl)purine |
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