Organocatalytic activation of TMSCN by basic ammonium salts for efficient cyanation of aldehydes and imines |
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| Authors: | I. Victor Paul Raj |
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| Affiliation: | Chemical Engineering and Process Development Division, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India |
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| Abstract: | Basic ammonium salts act as highly effective catalysts for the cyanosilylation of aldehydes and in Strecker-type aminonitrile synthesis using TMSCN as cyanide source at 25 °C under extremely mild conditions, affording very good to excellent yields of silylated cyanohydrins and α-aminonitriles. |
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| Keywords: | Aldehydes Aminonitriles Cyanosilylation Cyanohydrin Multicomponent reactions TMSCN |
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