An efficient synthesis of optically pure α-alkyl-β-azido- and α-alkyl-β-aminoalanines via ring opening of 3-amino-3-alkyl-2-oxetanones |
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Authors: | Adam Kudaj |
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Affiliation: | Institute of Organic Chemistry, Technical University, 90-924 ?ód?, ?eromskiego 116, Poland |
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Abstract: | N-Boc-α-alkylserine β-lactones on ring opening with sodium azide provide N-Boc-α-alkyl-β-azidoalanines, as N-protected amino acids are suitable for direct incorporation into peptides. N-Boc-α-alkyl-β-azidoalanines can be transformed by catalytic hydrogenation into the corresponding N-Boc-α-alkyl-β-aminoalanines. |
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Keywords: | α-Alkyl-β-azidoalanines α-Alkyl-β-aminoalanines N-Boc-α-alkylserine β-lactones α,α-Disubstituted amino acids Mitsunobu reaction |
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