Reaction of pyridine N-oxides with Grignard reagents: a stereodefined synthesis of substituted dienal oximes |
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| Authors: | Hans Andersson,Mikael Bjö rklund,Fredrik Almqvist |
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| Affiliation: | a Department of Chemistry, Umeå University, SE-90187 Umeå, Sweden
b ACADIA Pharmaceuticals AB, Medeon Science Park S-20512, Malmö, Sweden |
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| Abstract: | Rapid addition of Grignard reagents to pyridine N-oxides under mild conditions gave stereodefined dienal oximes in good to excellent yields. This reaction provides an efficient access to substituted olefins with defined stereochemistry that are potentially of interest as bioactives themselves or as versatile synthetic intermediates. |
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