Aza-Morita-Baylis-Hillman-type reactions: highly enantioselective organocatalytic addition of unmodified α,β-unsaturated aldehydes to N-Boc protected imines |
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Authors: | Jan Vesely |
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Institution: | Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden |
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Abstract: | Highly enantioselective catalytic routes to Boc protected aza-Morita-Baylis-Hillman-type products are presented. The organocatalytic asymmetric reactions between unmodified α,β-unsaturated aldehydes and N-Boc protected aryl imines proceed with excellent chemo- and enantioselectivity to give the corresponding compounds in good yields with 97-99% ee. |
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