Copper-free PdCl2/PPh3-catalyzed Sonogashira coupling reaction of aryl bromides with terminal alkynes in water |
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| Authors: | Jin Tao Guan |
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| Affiliation: | Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China |
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| Abstract: | A simple, copper-free and efficient catalytic system for the Sonogashira coupling reaction of aryl bromides with terminal alkynes in pure water has been developed. The use of PdCl2/PPh3 in the presence of pyrrolidine allows the coupling reaction to proceed at 120 °C in moderate to excellent yields. |
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| Keywords: | Water Copper-free Aryl bromides Sonogashira coupling reaction |
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