Cyclodidemniserinol trisulfate, a sulfated serinolipid from the Palauan ascidian Didemnum guttatum that inhibits HIV-1 integrase |
| |
Authors: | Mitchell S S Rhodes D Bushman F D Faulkner D J |
| |
Institution: | Scripps Institution of Oceanography, University of California at San Diego, La Jolla 92093-0212, USA. |
| |
Abstract: | structure--see text] Bioassay-guided fractionation of extracts of the Palauan ascidian Didemnum guttatum led to the isolation of cyclodidemniserinol trisulfate (1) as an inhibitor of HIV-1 integrase, which is an attractive target for anti-retroviral chemotherapy. The structure of cyclodidemniserinol trisulfate (1), the stereochemistry of which was only partially determined, was elucidated by interpretation of NMR and mass spectral data. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|