The effect of temperature and molar mass on the (liquid + liquid) equilibria of (poly ethylene glycol dimethyl ether + di-sodium hydrogen citrate + water) systems: Experimental and correlation |
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| Affiliation: | 1. Foundation IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, University of Milan, Pediatric Emergency Department, Milan, Italy;2. Università della Svizzera Italiana, Lugano, Switzerland;3. University Children''s Hospital, Inselspital, and University of Bern, Bern, Switzerland;1. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran;2. Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Sciences, Tabriz, Iran;3. Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran;4. Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;5. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;6. Faculty of Pharmacy, Near East University, PO BOX: 99138, Nicosia, North Cyprus, Mersin 10, Turkey;1. Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;2. Department of Physical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran;3. Department of Chemistry, University of North Texas, Denton, TX 76203-5070, USA;4. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran;5. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
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| Abstract: | The (liquid + liquid) equilibrium for the {polyethylene glycol dimethyl ether 2000 (PEGDME2000) + di-sodium hydrogen citrate + H2O} system was studied at T = (298.15, 308.15 and 318.15) K and atmospheric pressure (≈85 kPa). The free energies, enthalpies and entropies of cloud points were calculated in order to investigate the driving force formation of this two-phase system. To investigate the effect of molar mass of the polymer on the binodals and tie-lines, similar measurements were also made at T = 298.15 K on this two-phase system consisting of the PEGDME with molar masses of 500 and 250 g ⋅ mol−1. The effective excluded volume model was used for representation of the phase-forming ability in PEGDME systems. An empirical and the Merchuck equations with the temperature dependency were used to correlate the binodal curves. The Othmer–Tobias and Bancraft and Setschenow equations, the osmotic virial and the extended NRTL models were used to fit the tie-line data. |
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| Keywords: | Poly ethylene glycol di-methyl ether Di-sodium hydrogen citrate EEV model Extended NRTL model |
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