Measuring and validation for isothermal solubility data of solid 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one (nobiletin) in supercritical carbon dioxide |
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| Affiliation: | 1. Laboratorio de Termodinámica de Procesos, Departamento de Ingeniería Química y Ambiental, Universidad Técnica Federico Santa María, Avda. España 1680, Valparaíso, Chile;2. Centro de Investigación en Alimentación y Desarrollo, A.C., Carretera a La Victoria km. 0.6, Hermosillo, México;3. Departamento de Ingeniería Química y Bioprocesos, Pontificia Universidad Católica de Chile, Avda. Vicuña Mackenna 4860, Santiago, Chile;1. Research Scholar, Department of Physics, Govt. Arts College, Kumbakonam, Tamilnadu 612 002, India;2. Department of Physics, Meenakshi Ramasamy Arts & Science College, Thathanur, Ariyalur (DT), TN 621 804, India;3. Department of Physics, Govt. Arts College, Kumbakonam, Tamilnadu 612 002, India;4. Research Centre for Solar Energy, Department of Physics, Koneru Lakshmaiah Education Foundation, Green Fields, Guntur District, Vaddeswaram, Andhra Pradesh 522502, India;5. Mechanical Engineering Department, Government Engineering College Patan, Gujarat, India;6. Department of Electronics and Communication Engineering, Swami Keshvanand Institute of Technology, Ramnagariya Rd, Shivam Nagar, Jagatpura, Jaipur, Rajasthan 302017, India |
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| Abstract: | Isothermal solubility of 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one (nobiletin) in supercritical carbon dioxide at temperatures of (313, 323 and 333) K and pressures from (18 to 31) MPa was measured using an analytic-recirculation methodology, with direct determination of the molar composition of the carbon dioxide-rich phase by using high performance liquid chromatography. Results indicated that the range of the measured solubility of nobiletin was from 107 · 10−6 mol · mol−1 at T = 333 K and 18.35 MPa to 182 · 10−6 mol · mol−1 at T = 333 K and 31.40 MPa, with a temperature crossover around 18 MPa. The validation of the experimental solubility data was carried out by using three approaches, namely, estimation of combined expanded uncertainty for each solubility data point from experimental parameters values (⩽77 · 10−6 mol · mol−1); thermodynamic consistency, verified utilizing a test adapted from tools based on Gibbs–Duhem equation and solubility modelling results; and, self-consistency, proved by correlating the solubility data with a semi-empirical model as a function of temperature, pressure and pure CO2 density. |
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| Keywords: | Solubility Nobiletin Supercritical carbon dioxide Dispersion Modelling |
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