Enyne versus diene RCM in the synthesis of cyclopentene derivatives toward the A ring of FR182877 |
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| Authors: | Funel Jacques-Alexis Prunet Joëlle |
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| Affiliation: | Laboratoire de Synthèse Organique, UMR CNRS 7652, Ecole Polytechnique, DCSO, F-91128 Palaiseau, France. |
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| Abstract: | The A ring of FR182877, exemplified by ent-4-b,c, has been synthesized, involving an enyne RCM as the key step. A systematic comparison of enyne vs diene RCM for the formation of cyclopentene derivatives showed that the latter metathesis proceeds much more easily even for this ring size. |
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