Unraveling the mystery surrounding cholesterol's condensing effect |
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Authors: | Cao Honghua Tokutake Nobuya Regen Steven L |
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Affiliation: | Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania 18015, USA. |
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Abstract: | The results of nearest-neighbor recognition experiments that have been carried out with exchangeable dimers derived from 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine, in the presence of cholesterol, dihydrocholesterol, coprostanol, cholestane, cholesteryl methy ether, and sitosterol, provide strong support for a condensing mechanism in which the flexible acyl chains of the phospholipids complement, perfectly, the shape of neighboring sterols, thereby leading to a high number of hydrophobic contacts and tight packing. |
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