Reusable polymer-supported catalyst for the [3+2] Huisgen cycloaddition in automation protocols |
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Authors: | Girard Christian Onen Esra Aufort Marie Beauvière Sophie Samson Edmond Herscovici Jean |
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Institution: | Inserm, U640, Paris, F-75006 France. christian-girard@enscp.fr |
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Abstract: | reaction: see text] A polymer-supported catalyst for Huisgen's 3+2] cycloaddition reaction between azides and alkynes was prepared from copper(I) iodide and Amberlyst A-21. This catalyst was then used in an automated synthesis of 1,4-disubstituted 1,2,3-triazoles giving access to these products in good yields. The catalyst has shown good activity, stability, and recycling capabilities. |
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