One‐pot fabrication of robust interpenetrating hydrogels via orthogonal click reactions |
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| Authors: | Takuya Murakami Hugh R Brown Craig J Hawker |
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| Institution: | 1. Materials Research Laboratory, University of California, Santa Barbara, California;2. Yokkaichi Research Center, JSR Corporation, Mie, Japan;3. ARC Centre of Excellence in Electromaterials Science and Intelligent Polymer Research Institute, University of Wollongong, Wollongong, New South Wales, Australia;4. Materials Department, and Department of Chemistry and Biochemistry, University of California, Santa Barbara, California |
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| Abstract: | Interpenetrating polymer network (IPN) hydrogels have been fabricated through a facile one‐pot approach from tetra/bifunctional telechelic macromonomers with epoxy, amine, azide, and alkyne groups by orthogonal double click reactions: epoxy‐amine reaction and copper‐catalyzed azide‐alkyne cycloaddition. Both the crosslinked networks are simultaneously constructed in water from the biocompatible poly (ethylene glycol)‐based macromonomers. The crosslinking density of each network was finely tuned by the macromonomer structure, permitting control of network molecular weights between crosslinks of the final gels. Compared to corresponding single network gels, the IPN gels containing both tightly and loosely crosslinked networks exhibited superior mechanical properties with shear moduli above 15 kPa and fracture stresses over 40 MPa. The synthetic versatility of this one‐pot approach will further establish design principles for the next generation of robust hydrogel materials. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016 , 54, 1459–1467 |
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| Keywords: | azide– alkyne cycloaddition click chemistry double network epoxy‐amine reaction hydrogels hydrophilic polymers interpenetrating networks (IPN) poly(ethylene glycol) polyethers |
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