Antibacterial poly(ethylene glycol) hydrogels from combined epoxy‐amine and thiol‐ene click reaction |
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| Authors: | Chao Zhou Vinh X. Truong Yue Qu Trevor Lithgow Guodong Fu John S. Forsythe |
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| Affiliation: | 1. School of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu Province, China;2. Department of Materials Science and Engineering, Monash Institute of Medical Engineering, Monash University, Clayton, Victoria, Australia;3. Department of Microbiology & Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia |
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| Abstract: | Antibacterial hydrogels containing quaternary ammonium (QA) groups were prepared via a facile thiol‐ene “click” reaction using multifunctional poly(ethylene glycol) (PEG). The multifunctional PEG polymers were prepared by an epoxy‐amine ring opening reaction. The chemical and physical properties of the hydrogels could be tuned with different crosslinking structures and crosslinking densities. The antibacterial hydrogel structures prepared from PEG Pendant QA were less well‐defined than those from PEG Chain‐End QA. Furthermore, functionalization of the PEG‐type hydrogels with QA groups produced strong antibacterial abilities against Staphylococcus aureus, and therefore has the potential to be used as an anti‐infective material for biomedical devices. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016 , 54, 656–667 |
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| Keywords: | antibacterial hydrogel epoxy‐amine ring opening reaction quaternary ammonium thiol‐ene click chemistry |
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