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Poly(2‐oxazoline) hydrogels crosslinked with aliphatic bis(2‐oxazoline)s: Properties,cytotoxicity, and cell cultivation
Authors:Anna Zahoranová  Zuzana Kroneková  Miroslav Zahoran  Dušan Chorvát Jr.  Ivica Janigová  Juraj Kronek
Affiliation:1. Polymer Institute of the Slovak Academy of Sciences, Slovakia;2. Department of Experimental Physics, Faculty of Mathematics, Physics and Informatics, Comenius University, Slovakia;3. International Laser Center, Slovakia
Abstract:A series of hydrogels from 2‐ethyl‐2‐oxazoline and three bis(2‐oxazoline) crosslinkers—1,4‐butylene‐2,2′‐bis(2‐oxazoline), 1,6‐hexamethylene‐2,2′‐bis(2‐oxazoline), and 1,8‐octamethylene‐2,2′‐bis(2‐oxazoline)—are prepared. The hydrogels differ by the length of aliphatic chain of crosslinker and by the percentage of crosslinker (2–10%). The influence of the type and the percentage of the crosslinker on swelling properties, mechanical properties, and state of water is studied. The equilibrium swelling degree in water ranges from 2 to 20. With a proper selection of the crosslinker, Young's modulus can be varied from 10 kPa to almost 100 kPa. To evaluate the potential for medical applications, the cytotoxicity of extracts and the contact toxicity toward murine fibroblasts are measured. The hydrogels with the crosslinker containing a shorter aliphatic exhibit low toxicity toward fibroblast cells. Moreover, the viability and the proliferation of pancreatic β‐cells incubated inside hydrogels for 12 days are analyzed. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016 , 54, 1548–1559
Keywords:biocompatibility  bis(2‐oxazoline)  cell cultivation  cytotoxicity  hydrogels  mechanical properties  poly(2‐oxazoline)  swelling
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