Synthesis,characterization and in vitro cytotoxicity of homobimetallic complexes of palladium(II) with 2‐thiouracil ligands. Crystal structure of [Pd2(TU)(PPh3)3Cl2] |
| |
| Authors: | Farkhanda Shaheen Amin Badashah Marcel Gielen L Marchio Dick de Vos M Kaleem Khosa |
| |
| Institution: | 1. Department of Chemistry, Quaid‐i‐Azam University, Islamabad 45320, Pakistan;2. Vrije Universiteit Brussel, Faculty of Engineering, HNMR Unit, B‐1050 Brussels, Belgium;3. Dipartimento di Chimica Generale ed Inorganica, Chimica Analitica, Chimica Fisica, Universitia de Parma, 17/A 43100, Parma, Italy;4. Pharmachemie BV, PO Box 552, 2003 RN Haarlem, The Netherlands;5. Department of Chemistry, Government College University Faisalabad, Pakistan |
| |
| Abstract: | Square planar metallic and homonuclear bimetallic complexes of Pd(II) with 2‐thiouracil (HTU) and organophosphines have been synthesized and characterized by FT‐IR and multinuclear 1H, 13C, 31P NMR spectroscopy. The thiouracil ligand TU acts as bidentate, is bound through the thioxo moiety and the endo amino group and forms a bridge between a PdCl(R3P) and a PdCl(R3P)2 moiety R3P = Ph3P (o‐tolyl)3P, ClPh2P] in the homonuclear bimetallic complexes. The square planar geometry around Pd(II) has been confirmed for these complexes by a single‐crystal X‐ray diffraction study of compound 1 , Pd2(TU)(PPh3)3Cl2]. These compounds were also screened against human tumor cell lines and showed promising in vitro cytotoxicity. Copyright © 2007 John Wiley & Sons, Ltd. |
| |
| Keywords: | palladium organophosphines thiouracil cytotoxicity |
|
|
