Gd-AAZTA]-: a new structural entry for an improved generation of MRI contrast agents |
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Authors: | Aime Silvio Calabi Luisella Cavallotti Camilla Gianolio Eliana Giovenzana Giovanni B Losi Pietro Maiocchi Alessandro Palmisano Giovanni Sisti Massimo |
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Institution: | Dipartimento di Chimica IFM, Università degli Studi di Torino, Via P. Giuria 7, I-10125 Torino, Italy. silvio.aime@unito.it |
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Abstract: | An innovative MRI contrast agent based on the unprecedented and easily obtained ligand AAZTA is described. The simple and straightforward synthesis of the ligand, together with the potentiometric and relaxometric behavior of the corresponding Gd(III) chelate, is reported. The complex Gd(AAZTA)]- shows outstanding magnetic properties connected with high thermodynamic stability in aqueous solution and a nearly complete inertness toward the influence of bidentate endogenous anions, placing this compound as one of the most promising candidates for the development of high performance MRI contrast agents. |
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