A stereoselective three-component reaction: The facile synthesis of fluorinated tetrahydropyrimido[1,2-b]benzothiazoles |
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| Authors: | A. Shaabani A. Rahmati A. H. Rezayan H. R. Khavasi |
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| Affiliation: | 1. Department of Chemistry, Shahid Beheshti University, P.O. Box 19396-4716, Tehran, Iran
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| Abstract: | A one-pot, catalyst- and solvent-free approach has been developed for the stereoselective synthesis of fluorinated tetrahydropyrimido[1,2-b]benzothiazoles. The three-component condensation reaction of an aldehyde and a trifluoromethyl ??-dicarbonyl compound in the presence of 2-aminobenzothizole occurs in high yields at 90 °C. |
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