Certain O,O-dialkyl-S-(β-N,N-cyclohexylmethylaminoethyl)thiophosphates,selective inhibitors of butyrylcholinesterase |
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| Authors: | A. P. Brestkin I. L. Brik L. I. Ginetsinskaya N. N. Godovikov M. I. Kabachnik E. G. Kireeva S. A. Trifonova |
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| Affiliation: | 1. Institute of Heteroorganic Compounds of the Academy of Sciences of the USSR, Moscow
2. I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Academy of Sciences of the USSR, Leningrad
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| Abstract: | | 1. | O,O-Diisopropyl-, O,O-dipropyl, and O,O-dibutyl-S-( -N, N-cyclohexy]methylaminoethyl)thiophosphates and their methiodides were synthesized and their anticholinesterase activity was determined in relation to butyrylcholinesterase from horse blood serum and acetylcholinesterase from human erythrocytes. | | 2. | O,O-Diisopropyl-S-(-N, N-cyclohexylmethylammoethyl)thiophosphate and its methiodide display the largest effect of selective effect in relation to butyrylcholinesterase. |
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