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3-Diethylaminopropyl-bearing glycol chitosan as a protein drug carrier |
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| Authors: | Baik Hye Jung Oh Nam Muk Oh Young Taik Yoo Na Young Park So Young Oh Kyung Taek Youn Yu Seok Lee Eun Seong |
| Institution: | a Division of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Republic of Korea;b Department of Diagnostic Radiology, Yonsei University College of Medicine, Seodaemun-ku Shinchon-dong 134, Seoul 120-752, Republic of Korea;c College of Pharmacy, Chung-Ang University, 221 Heukseok dong, Dongjak-gu, Seoul 155-756, Republic of Korea;d College of Pharmacy, Pusan National University, Jangjun-dong, Geumjeong-gu, Busan 609-735, Republic of Korea |
| Abstract: | Polysaccharidic nanogels were fabricated with bovine serum albumin (BSA) and a glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups. These nanogels were investigated to evaluate their cellular uptake in HeLa cells and in vivo fate in nude mice tumor model. Unlike free BSA, GCS-g-DEAP/BSA nanogels improved cellular uptake of BSA. Furthermore, this system led to an enhanced blood circulation and a high accumulation of BSA in the tumor site. Our collective results strongly support that GCS-g-DEAP/BSA nanogel is a potential carrier system for high molecular weight proteins. |
| Keywords: | Polysaccharidic nanogels Glycol chitosan Bovine serum albumin Ph-sensitivity |
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