Synthesis of oleanolic disaccharide derivatives |
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| Authors: | Shu Chen Peia Jian Bo Wua Fan Leia Shan Qianb Li Haia Yong Wua a |
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| Affiliation: | Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China, ; Bioengineering College, Xihua University, Chengdu 610039, China |
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| Abstract: | Oleanolic acid 1 exists widely in food,medicinal herbs and other plants and possesses many attractive biological activities. Recently,some oleanolic derivatives were reported to have interesting anti-tumor activities.Herein,using association principle of drug design,OA disaccharide 17 was designed and synthesized by coupling a-L-rhamnopyranosyl-(1→2)-a-L-arabinopyranosyl disaccharide moiety,which has proved to be a unique sugar sequence with strongly antitumor activity,and modified OA with a nitrile at C-17. |
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| Keywords: | Oleanolic acid Rhamnopyranosyl Arabinopyranosyl Anti-tumor Association principle |
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