Determination of paracetamol in pharmaceutical formulations using a sequential injection system |
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Authors: | van Staden J Koos F Tsanwani M Mutshutshu |
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Affiliation: | Department of Chemistry, University of Pretoria, Pretoria 0002, South Africa |
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Abstract: | A simple method for the rapid determination of paracetamol in pharmaceutical formulations is described. The method involves oxidation of paracetamol by potassium hexacyanoferrate(III) and a subsequent reaction with phenol in the presence of ammonia. The blue complex formed is measured at 630 nm. The system has a sample frequency of 27 samples per h with a detection limit of 0.2 mg l−1. The calibration curve is linear up to 60 mg l−1 with a relative standard deviation of 1.2% (n=10). |
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Keywords: | Sequential injection analysis Paracetamol Sodium hydroxide Pharmaceutical formulations |
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