Controlling electron trap depth to enhance optical properties of persistent luminescence nanoparticles for in vivo imaging |
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Authors: | Maldiney Thomas Lecointre Aurélie Viana Bruno Bessière Aurélie Bessodes Michel Gourier Didier Richard Cyrille Scherman Daniel |
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Affiliation: | Unité de Pharmacologie Chimique et Génétique et d'Imagerie, CNRS, UMR 8151, Paris, F-75270 cedex, France. |
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Abstract: | Focusing on the use of nanophosphors for in vivo imaging and diagnosis applications, we used thermally stimulated luminescence (TSL) measurements to study the influence of trivalent lanthanide Ln(3+) (Ln = Dy, Pr, Ce, Nd) electron traps on the optical properties of Mn(2+)-doped diopside-based persistent luminescence nanoparticles. This work reveals that Pr(3+) is the most suitable Ln(3+) electron trap in the diopside lattice, providing optimal trap depth for room temperature afterglow and resulting in the most intense luminescence decay curve after X-ray irradiation. This luminescence dependency toward the electron trap is maintained through additional doping with Eu(2+), allowing UV-light excitation, critical for bioimaging applications in living animals. We finally identify a novel composition (CaMgSi(2)O(6):Eu(2+),Mn(2+),Pr(3+)) for in vivo imaging, displaying a strong near-infrared afterglow centered on 685 nm, and present evidence that intravenous injection of such persistent luminescence nanoparticles in mice allows not only improved but highly sensitive detection through living tissues. |
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