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One-pot synthesis of hydrogen phosphonate derivatives of d4T and AZT
Authors:Sun Xiao Bin  Kang Jian Xun  Zhao Yu Fen
Institution:Key Laboratory of Bio-organic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Science and Engineering, Tsinghua University, Beijing 100084, China.
Abstract:A simple and one-pot route for the synthesis of d4T or AZT hydrogen phosphonate derivatives via reaction of d4T or AZT with phosphorus trichloride, then alcoholysis and dealkylation in the presence of the corresponding alcohol is described.
Keywords:
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