Biosynthesis of pantothenate |
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Authors: | Webb Michael E Smith Alison G Abell Chris |
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Affiliation: | University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. mew23@cantab.net |
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Abstract: | Pantothenate is an essential metabolite for all biological systems, however, the biosynthetic pathway is limited to plants, eubacteria and archaea. This suggests that the pathway is a strong candidate for the discovery of novel antibiotic and herbicidal compounds. The enzymology of this short pathway in both bacteria and plants is discussed in detail. In addition a short survey of studies of the whole pathway, and a discussion of both the metabolism and the transport of pantothenate are included. |
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