Synthesis,structure and cytotoxic activity of cobalt(II), nickel(II) and copper(II) chloride complexes with acetamidrazones |
| |
| Authors: | Ponticelli Gustavo Cocco M Teresa Congiu Cenzo Onnis Valentina Ianelli Sandra Cossu Francesco |
| |
| Institution: | (1) Dipartimento di Chimica Inorganica ed Analitica, Universita' degli Studi di Cagliari, Cittadella di Monserrato, 09042 Monserrato, Cagliari, Italy;(2) Dipartimento di Tossicologia, Universita' degli Studi di Cagliari, Via Ospedale 72, 09124 Cagliari, Italy;(3) Dipartimento di Chimica Generale ed Inorganica, Chimica Analitica, Chimica Fisica, Universita' di Parma, Viale delle Scienze, 43100 Parma, Italy;(4) Istituto di Radiologia, Facoltà di Medicina, Universita' degli Studi di Cagliari, Via Ospedale 46, 09124 Cagliari, Italy |
| |
| Abstract: | CoII, NiII and CuII chloride complexes with acetamidrazone derivatives (L
1
)–(L
8
) have been prepared, by reacting the corresponding metal chloride with the ligand in a 1:2 ratio, and characterised by chemical analysis and physical measurements. The ligand behaviour and the geometry have been assigned on the basis of i.r. spectroscopy, electronic reflectance spectra and molar conductivity values and only, where possible, the geometry has been confirmed as octahedral by X-ray structure determination. Complexes cytotoxicity on a human cellular line of adenocarcinoma was also tested. Three of the complexes present a weak cytotoxicity in vitro. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
