Agesamides A and B, bromopyrrole alkaloids from sponge Agelas species: application of DOSY for chemical screening of new metabolites |
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Authors: | Tsuda Masashi Yasuda Tetsuro Fukushi Eri Kawabata Jun Sekiguchi Mitsuhiro Fromont Jane Kobayashi Jun'ichi |
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Affiliation: | Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. |
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Abstract: | Diffusion-ordered NMR spectroscopy (DOSY) is a versatile and powerful NMR technique and a noninvasive analytical method for mixture analysis that does not require prior physical separation of the analytes. In our search for new metabolites from natural resources, DOSY was applied for constituent analysis of crude bromopyrrole fractions separated from an Okinawan marine sponge Agelas sp. so that two new bromopyrrole alkaloids, agesamides A (1) and B (2), have been isolated. The structures and relative stereochemistry of 1 and 2 were elucidated from spectroscopic data. |
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