Facile synthesis of enantiopure 1,1′-binaphthyl-2,2′-dicarboxylic acid via lipase-catalyzed kinetic resolution |
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Authors: | Toshiyuki Furutani Masanori Hatsuda Ritsuo Imashiro Masahiko Seki |
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Affiliation: | Product & Technology Development Laboratory, Tanabe Seiyaku Co., Ltd, 3-16-89, Kashima, Yodogawa-ku, Osaka 532-8505, Japan |
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Abstract: | Enantiopure 1,1′-binaphthyl-2,2′-dicarboxylic acids (R)-1 and (S)-1 have been synthesized through the lipase-catalyzed kinetic resolution of the racemic 2,2-bis(hydroxymethyl)-1,1′-binaphthyl (±)-2 and subsequent oxidation of the hydroxymethyl groups. |
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