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Flow chemistry approach for partial deuteration of alkynes: synthesis of deuterated taxol side chain |
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| Authors: | S. Chandrasekhar B.V.D. VijaykumarB. Mahesh Chandra Ch. Raji ReddyP. Naresh |
| Affiliation: | a Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India b Center for Nuclear Magnetic Resonance, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| Abstract: | The partial deuteration of alkynes proceeds via a flow chemistry approach under Lindlar’s heterogeneous catalysis to provide cis-dideuterated olefins in good yields. Further, dideuterated olefin has been successfully utilized for Sharpless asymmetric dihydroxylation followed by Mitsunobu reaction for the synthesis of deuterated taxol side chain. |
| Keywords: | Flow chemistry Partial deuteration Sharpless asymmetric dihydroxylation Deuterated taxol side chain |
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